Grape (Vitis vinifera)

Grape (Vitis vinifera) Seed Extract (95% Proanthocyanidins)(France) – 175 mg

What is Grape (Vitis vinifera) Seed Extract?

Grape seed extract is made from the seeds of wine grapes. The active ingredient is Oligomeric procyanidins1, and Grape Seed Extract also goes by alternate names of GSE, OPC, oligomeric procyanidins, and procyanidin. 

What does it help with in the body? 

Grape Seed Extract is known for its ability to reduce inflammation. It has shown benefit in certain conditions, including Chronic venous insufficiency and edema, wound healing, Skin (antiaging and ultraviolet, or UV, protection), Eye stress due to glare, Age-related macular degeneration, Viral infection, High cholesterol, Atherosclerosis, Heart disease and Metabolism.

What have the studies shown?

A 2019 review of 15 studies involving 825 participants suggested that grape seed extract might help lower levels of LDL cholesterol, total cholesterol, triglycerides, and the inflammatory marker C-reactive protein. 

A study focusing on weight loss in obese patients showed that Grape Seed Extract had effects in reducing anthropometric measurements and inflammatory markers in obese or overweight individuals, and may play an effective role in the treatment of obesity.

Study: A randomized, double-blind clinical trial was performed on 40 obese or overweight subjects who were randomly assigned to receive GSE (300 mg/day) or placebo for a period of 12-weeks. Both groups were under a restricted calorie diet (RCD)(~250 kcal lower than the estimated energy requirement). 

The reductions of body weight, body mass index, waist circumference, and waist to hip ratio were significantly higher in the GSE group compared to the placebo group (P = 0.045, 0.033, 0.029, and 0.021, respectively). Lower levels of neuropeptide Y, tumor necrosis factor alpha, and high sensitivity C-reactive protein were observed in the GSE group in comparison with the placebo group (P = 0.041, 0.001, and 0.034, respectively).

What are some contraindications?

Avoid if pregnant or breastfeeding due to lack of safety data; do not combine with blood thinners; avoid taking before surgery

It’s possibly unsafe if you have a bleeding disorder or are going to have surgery or if you take anticoagulants (blood thinners), such as warfarin or aspirin

Source: https://www.verywellhealth.com/the-benefits-of-grape-seed-extract-89055

For more information about Grape Seed Extract: 

https://www.nccih.nih.gov/health/grape-seed-extract

https://pubmed.ncbi.nlm.nih.gov/31713941/

Compare to: Thorne – O.P.C. 100 ($47